Botox, Dysport, and Xeomin: The Difference Between the Three

With all the different types of injectables and fillers, it is easy to feel confused when picking which is best for you. One of the most common questions we receive is, “What is the difference between Botox, Dysport, and Xeomin?”. ZONA Med Spa is a top Med Spa in Scottsdale. In that we cater to patients from all over the valley and offer as many services as possible to ensure that ZONA is your one stop shop. Due to this, we offer all three forms of wrinkle freezing injectables. The following paragraphs will explain how wrinkles are formed and compare and contrast between the three injectable neuromodulators.

How Wrinkles are even formed?

Creases on the forehead and frown lines between the eyebrows are the result of muscle contractions combined with a loss of skin elasticity. Sun exposure, hormone loss, genetics or the aging process can cause this loss of elasticity. The creases and lines that form in the skin can make you look tired, stressed and older than your age. Who wants to look old and tired? I am sure you don’t…you want to look as young and outgoing as you feel.

How Injectable Neuromodulators work?

Botox, Dysport, and Xeomin all work on the muscles under the skin to smooth moderate to severe facial lines. They interrupt the signals between nerves and muscles, resulting in a reduction in the muscle contractions that cause lines to appear as a wrinkle. People typically receive these injectables in the forehead, crow’s feet, between the brows or “bunny lines”, and fine lines around the lips. Although, these injections can additionally be used to reduce migraines, stop jaw clenching and lift eyebrows, and reduce excessive sweating.

The Difference?

While Botox, Dysport, and Xeomin are all made up of Botulinum toxin Type A, their formula differs in the amount of accessory proteins they obtain. Botox has the most accessory proteins, thus is it considered the ‘heaviest’ injectable. Next down the line is Dysport, which has a considerably lower amount of added proteins.  Xeomin has no accessory proteins, thus making it a ‘pure’ version of the botulinum toxin.  Due to the large amount of accessory proteins Botox contains, patients may build up a tolerance to the injectable requiring the injector to increase the dose or switch to another option like Dysport or Xeomin.  Dysport further stands out from the other two toxins because it kicks in quicker and typically lasts longer. This leads to the benefit of saving hundreds of dollars by only having to come to the Med Spa 3 times a year as opposed to 4-5 times with Botox and Xeomin.  For this reason, we at ZONA primary inject Dysport. The last major difference between the neuromodulators is the amount of units needed. About 20 units of Botox and Xeomin is equivalent to 50 units of Dysport. Therefore, the total price ends up being just about the same regardless of which injectable you chose at the time of treatment.

Below are two quick cheat sheets of the main differences reviewed:

Proteins Longevity Price
Botox Most 3-4 months $9.99 a unit
Xeomin None 3-4 months $9.99 a unit
Dysport Some 4-6 months $3.99 a unit


Between Brows Forehead Crow’s Feet
Botox 20-40 Units 8-20 6-15 per side
Xeomin 20-40 8-20 6-15
Dysport 30-70 25-40 15-30

If you’re looking to decrease lines or wrinkles but unsure which injectable is best for you, ZONA Med Spa in Scottsdale AZ can help! Additionally, please remember that the specified range of units needed per area in the chart above is a generalization. For exact pricing, please come in for a complimentary consultation!


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